The English titles of "Mr", "Mrs", "Miss", "Ms" are all irrelevant as all people are referred to by the suffix -san ( さん ? ) . The more polite -sama ( 様 ? ) suffix is used only in certain contexts with people who are superior in social standing to you, and is also gender-neutral in usage. The most polite suffix -dono ( 殿 ? ) usually, but not always, refers to males, and is rarely used in modern speech. Both -sama ( 様 ? ) and -dono ( 殿 ? ) should be used with caution, and only with more than basic understanding of Japanese social structures.